Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정환 | - |
dc.date.accessioned | 2016-08-28T12:08:53Z | - |
dc.date.available | 2016-08-28T12:08:53Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1476-7058 | - |
dc.identifier.other | OAK-8438 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222335 | - |
dc.description.abstract | Objective.There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed 10 functional polymorphisms in 9 genes involved in innate immune function. Methods.Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions. Results.Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-C1562T, and TNF receptor two M196R (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha-G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p < 0.05). Among African-American women, the odds of PTD were higher when both mother and child carried the TNFR2 R allele (multiplicative interaction p < 0.05). Conclusion.These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk. © 2012 Informa UK, Ltd. | - |
dc.language | English | - |
dc.title | Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 25 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 240 | - |
dc.relation.lastpage | 247 | - |
dc.relation.journaltitle | Journal of Maternal-Fetal and Neonatal Medicine | - |
dc.identifier.doi | 10.3109/14767058.2011.569614 | - |
dc.identifier.wosid | WOS:000300021600006 | - |
dc.identifier.scopusid | 2-s2.0-84856859323 | - |
dc.author.google | Jones N.M. | - |
dc.author.google | Holzman C. | - |
dc.author.google | Tian Y. | - |
dc.author.google | Witkin S.S. | - |
dc.author.google | Genc M. | - |
dc.author.google | Friderici K. | - |
dc.author.google | Fisher R. | - |
dc.author.google | Sezen D. | - |
dc.author.google | Babula O. | - |
dc.author.google | Jernigan K.A. | - |
dc.author.google | Chung H. | - |
dc.author.google | Wirth J. | - |
dc.contributor.scopusid | 정환(7404006411) | - |
dc.date.modifydate | 20211210153830 | - |