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Improved electrochemical microsensor for the real-time simultaneous analysis of endogenous nitric oxide and carbon monoxide generation

Title
Improved electrochemical microsensor for the real-time simultaneous analysis of endogenous nitric oxide and carbon monoxide generation
Authors
Park S.S.Kim J.Lee Y.
Ewha Authors
이영미
SCOPUS Author ID
이영미scopus
Issue Date
2012
Journal Title
Analytical Chemistry
ISSN
0003-2700JCR Link
Citation
vol. 84, no. 3, pp. 1792 - 1796
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An amperometric dual NO/CO microsensor was developed on the basis of a working electrode incorporating dual Pt microdisks (each diameter, 76 μm) and a Ag/AgCl reference electrode covered with a gas permeable membrane. One of the Pt disks was sequentially electrodeposited with Pt and Sn; the other Pt disk was deposited with Pt-Fe(III) oxide nanocomposites. The first showed activity for the oxidation of both NO and CO; the second showed activity only for NO oxidation. In the copresence of NO and CO, the currents measured at each electrode, respectively, represented the concentrations of CO and NO. The sensor showed high stability during the monitoring of organ tissue for at least 2.5 h and high selectivity to NO over CO at the Pt-Fe(III) oxide working electrode. Real-time coupled dynamic changes of NO and CO generated by a living C57 mouse kidney were monitored simultaneously and quantitatively in response to a NO synthase inhibitor (N G-nitro-l-arginine methyl ester), for the first time. CO was found to increase and NO decreased upon addition of the inhibitor, suggesting a possible reciprocal interaction between these endogenous gases. © 2011 American Chemical Society.
DOI
10.1021/ac2031628
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자연과학대학 > 화학·나노과학전공 > Journal papers
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