Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:47Z | - |
dc.date.available | 2016-08-28T12:08:47Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1598-5032 | * |
dc.identifier.other | OAK-8349 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222264 | - |
dc.description.abstract | Based on the thermosensitivity of Pluronic® F127 and the cytointeractability of Arg-Gly-Asp (RGD) sequences, RGD-modified F127 dimethacrylate (FM-RGD) hydrogel was investigated as a 3-dimensional culture matrix for chondrocytes. Chondrocytes were encapsulated in the hydrogel by radical copolymerization of FM-RGD and FM in the presence of cells. The FM-RGD hydrogel modulus could be modulated by temperature variation from 15 °C (1,300 Pa) to the culture temperature of 37 °C (8,900 Pa), at which the hydrogel provided a condrocyte-compatible microenvironment. Compared with the hydrogel prepared from F127 dimethacrylate (FM) without RGD, the RGD-modified hydrogel produced significant (p<0.01) improvements in cell proliferation, DNA production, and viability while allowing the chondrocytes to maintain their original spherical phenotypes. © 2012 The Polymer Society of Korea and Springer Netherlands. | * |
dc.language | English | * |
dc.title | Chondrocyte 3D-culture in RGD-modified crosslinked hydrogel with temperature-controllable modulus | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 106 | * |
dc.relation.lastpage | 111 | * |
dc.relation.journaltitle | Macromolecular Research | * |
dc.identifier.doi | 10.1007/s13233-012-0074-6 | * |
dc.identifier.wosid | WOS:000298883100015 | * |
dc.identifier.scopusid | 2-s2.0-84856215954 | * |
dc.author.google | Lee H. | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Moon H.J. | * |
dc.author.google | Choi J. | * |
dc.author.google | Park K. | * |
dc.author.google | Jeong B. | * |
dc.author.google | Han D.K. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |