DSpace at EWHA: N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region

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DC Field	Value	Language
dc.contributor.author	최선	*
dc.date.accessioned	2016-08-28T12:08:43Z	-
dc.date.available	2016-08-28T12:08:43Z	-
dc.date.issued	2012	*
dc.identifier.issn	0968-0896	*
dc.identifier.other	OAK-8307	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/222225	-
dc.description.abstract	Structure-activity relationships for the A-region in a series of N-4-t-butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamides as TRPV1 antagonists have been investigated. Among them, the 3-fluoro analogue 54 showed high binding affinity and potent antagonism for both rTRPV1 and hTRPV1 in CHO cells. Its stereospecific activity was demonstrated with marked selectivity for the (S)-configuration (54S versus 54R). A docking study of 54S with our hTRPV1 homology model highlighted crucial hydrogen bonds between the ligand and the receptor contributing to its potency. © 2011 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region	*
dc.type	Article	*
dc.relation.issue	1	*
dc.relation.volume	20	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	215	*
dc.relation.lastpage	224	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry	*
dc.identifier.doi	10.1016/j.bmc.2011.11.008	*
dc.identifier.wosid	WOS:000298633300022	*
dc.identifier.scopusid	2-s2.0-84855188641	*
dc.author.google	Kim Y.S.	*
dc.author.google	Kil M.-J.	*
dc.author.google	Kang S.-U.	*
dc.author.google	Ryu H.	*
dc.author.google	Kim M.S.	*
dc.author.google	Cho Y.	*
dc.author.google	Bhondwe R.S.	*
dc.author.google	Thorat S.A.	*
dc.author.google	Sun W.	*
dc.author.google	Liu K.	*
dc.author.google	Lee J.H.	*
dc.author.google	Choi S.	*
dc.author.google	Pearce L.V.	*
dc.author.google	Pavlyukovets V.A.	*
dc.author.google	Morgan M.A.	*
dc.author.google	Tran R.	*
dc.author.google	Lazar J.	*
dc.author.google	Blumberg P.M.	*
dc.author.google	Lee J.	*
dc.contributor.scopusid	최선(8659831000)	*
dc.date.modifydate	20240305081003	*