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Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline

Title
Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline
Authors
Lee S.H.Kim I.S.Li Q.R.Dong G.R.Jeong L.S.Jung Y.H.
Ewha Authors
정낙신
Issue Date
2011
Journal Title
Journal of Organic Chemistry
ISSN
0022-3263JCR Link
Citation
Journal of Organic Chemistry vol. 76, no. 24, pp. 10011 - 10019
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described (Figure presented). © 2011 American Chemical Society.
DOI
10.1021/jo201794k
Appears in Collections:
약학대학 > 약학과 > Journal papers
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