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Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline

Title
Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline
Authors
Lee S.H.Kim I.S.Li Q.R.Dong G.R.Jeong L.S.Jung Y.H.
Ewha Authors
정낙신
Issue Date
2011
Journal Title
Journal of Organic Chemistry
ISSN
0022-3263JCR Link
Citation
vol. 76, no. 24, pp. 10011 - 10019
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described (Figure presented). © 2011 American Chemical Society.
DOI
10.1021/jo201794k
Appears in Collections:
약학대학 > 약학과 > Journal papers
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