View : 13 Download: 0
Flt3 signaling-dependent dendritic cells protect against atherosclerosis
- Flt3 signaling-dependent dendritic cells protect against atherosclerosis
- Choi J.-H.; Cheong C.; Dandamudi D.; Park C.; Rodriguez A.; Mehandru S.; Velinzon K.; Jung I.-H.; Yoo J.-Y.; Oh G.; Steinman R.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- vol. 35, no. 5, pp. 819 - 831
- SCI; SCIE; SCOPUS
- Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells (DCs) in the intima. In contrast to aortic adventitial macrophages, CD11c +MHC II hi DCs were poorly phagocytic but were immune stimulatory. DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103 +CD11b - DCs and macrophage-colony stimulating factor (M-CSF)-dependent, CD14 +CD11b +DC-SIGN + monocyte-derived DCs. Both types expanded during atherosclerosis. By crossing Flt3 -/- to Ldlr -/- atherosclerosis-prone mice, we developed a selective and marked deficiency of classical CD103 + aortic DCs, and they were associated with exacerbated atherosclerosis without alterations in blood lipids. Concomitantly, the Flt3 -/-Ldlr -/- mice had fewer Foxp3 + Treg cells and increased inflammatory cytokine mRNAs in the aorta. Therefore, functional DCs are dominant in normal aortic intima and, in contrast to macrophages, CD103 + classical DCs are associated with atherosclerosis protection. © 2011 Elsevier Inc.
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.