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Expression of hepatocyte growth factor/c-met by RT-PCR in meningiomas

Title
Expression of hepatocyte growth factor/c-met by RT-PCR in meningiomas
Authors
Kim N.R.Chae Y.S.Lim W.J.Cho S.J.
Ewha Authors
임원정
SCOPUS Author ID
임원정scopus
Issue Date
2011
Journal Title
Korean Journal of Pathology
ISSN
1738-1843JCR Link
Citation
vol. 45, no. 5, pp. 463 - 468
Indexed
SCOPUS WOS scopus
Abstract
Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
DOI
10.4132/KoreanJPathol.2011.45.5.537
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의학전문대학원 > 의학과 > Journal papers
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