Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임원정 | - |
dc.date.accessioned | 2016-08-28T12:08:31Z | - |
dc.date.available | 2016-08-28T12:08:31Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.other | OAK-8158 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222102 | - |
dc.description.abstract | Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression. | - |
dc.language | English | - |
dc.title | Expression of hepatocyte growth factor/c-met by RT-PCR in meningiomas | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 45 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 463 | - |
dc.relation.lastpage | 468 | - |
dc.relation.journaltitle | Korean Journal of Pathology | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2011.45.5.537 | - |
dc.identifier.wosid | WOS:000297157100003 | - |
dc.identifier.scopusid | 2-s2.0-84856655644 | - |
dc.author.google | Kim N.R. | - |
dc.author.google | Chae Y.S. | - |
dc.author.google | Lim W.J. | - |
dc.author.google | Cho S.J. | - |
dc.contributor.scopusid | 임원정(8404516800) | - |
dc.date.modifydate | 20180329110650 | - |