Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-28T12:08:22Z | - |
dc.date.available | 2016-08-28T12:08:22Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0171-5216 | * |
dc.identifier.other | OAK-8058 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222020 | - |
dc.description.abstract | Purpose: Gastrokine 1 (GKN1) plays an important role in the gastric mucosal defense mechanism and also acts as a functional gastric tumor suppressor. The specific aim of this study was to determine the molecular mechanisms underlying GKN1 tumor suppressor activity in the progression of gastric cancers. Methods: We examined the effect of GKN1 on epithelial-mesenchymal transition (EMT) and cell migration in GKN1-transfected and recombinant GKN1-treated AGS gastric cancer cells using in vitro wound healing, microchemotaxis, and invasion assays. Results: In GKN1-transfected AGS cells, we observed inhibition of cell migration and invasion in wound healing, transwell and Matrigel assay. Also, GKN1-transfected and recombinant GKN1-treated AGS cells showed decreased levels of ROS and expression of phosphatidylinositol 3-kinase (PI3K)/Akt pathway proteins, concomitant with re-expression of E-cadherin and decreased expression of cytoplasmic and nuclear expression of β-catenin, slug, snail, fibronectin, and vimentin. Conclusions: These data suggest that the GKN1 gene may play an important role in the progression of sporadic gastric cancers via inhibition of EMT and cancer cell migration. © 2011 Springer-Verlag. | * |
dc.language | English | * |
dc.title | Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 137 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1697 | * |
dc.relation.lastpage | 1704 | * |
dc.relation.journaltitle | Journal of Cancer Research and Clinical Oncology | * |
dc.identifier.doi | 10.1007/s00432-011-1051-8 | * |
dc.identifier.wosid | WOS:000295989100013 | * |
dc.identifier.scopusid | 2-s2.0-80054769444 | * |
dc.author.google | Yoon J.H. | * |
dc.author.google | Kang Y.H. | * |
dc.author.google | Choi Y.J. | * |
dc.author.google | Park I.S. | * |
dc.author.google | Nam S.W. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Park W.S. | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |