Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-28T12:08:19Z | - |
dc.date.available | 2016-08-28T12:08:19Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-8023 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221992 | - |
dc.description.abstract | A series of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4triazolo[1,5- apyridin-6-yl)pyrazoles 14a-ae, 16a, 16b, and 21a-c has been prepared and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 4-([1,2,4triazolo[1,5-apyridin-6-yl)- N-(4-methoxyphenyl)-3-(6-methylpyridin-2-yl)-1H-pyrazole-1-carbothioamide (14n) inhibited ALK5 phosphorylation with IC 50 value of 0.57 nM and showed 94% inhibition at 100 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. © 2011 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 20 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6049 | * |
dc.relation.lastpage | 6053 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2011.08.064 | * |
dc.identifier.wosid | WOS:000295494500004 | * |
dc.identifier.scopusid | 2-s2.0-80052927702 | * |
dc.author.google | Jin C.H. | * |
dc.author.google | Krishnaiah M. | * |
dc.author.google | Sreenu D. | * |
dc.author.google | Subrahmanyam V.B. | * |
dc.author.google | Rao K.S. | * |
dc.author.google | Mohan A.V.N. | * |
dc.author.google | Park C.-Y. | * |
dc.author.google | Son J.-Y. | * |
dc.author.google | Sheen Y.Y. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |