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dc.contributor.author신윤용*
dc.contributor.author김대기*
dc.date.accessioned2016-08-28T12:08:19Z-
dc.date.available2016-08-28T12:08:19Z-
dc.date.issued2011*
dc.identifier.issn0960-894X*
dc.identifier.otherOAK-8023*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221992-
dc.description.abstractA series of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4triazolo[1,5- apyridin-6-yl)pyrazoles 14a-ae, 16a, 16b, and 21a-c has been prepared and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 4-([1,2,4triazolo[1,5-apyridin-6-yl)- N-(4-methoxyphenyl)-3-(6-methylpyridin-2-yl)-1H-pyrazole-1-carbothioamide (14n) inhibited ALK5 phosphorylation with IC 50 value of 0.57 nM and showed 94% inhibition at 100 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. © 2011 Elsevier Ltd. All rights reserved.*
dc.languageEnglish*
dc.titleSynthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors*
dc.typeArticle*
dc.relation.issue20*
dc.relation.volume21*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage6049*
dc.relation.lastpage6053*
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters*
dc.identifier.doi10.1016/j.bmcl.2011.08.064*
dc.identifier.wosidWOS:000295494500004*
dc.identifier.scopusid2-s2.0-80052927702*
dc.author.googleJin C.H.*
dc.author.googleKrishnaiah M.*
dc.author.googleSreenu D.*
dc.author.googleSubrahmanyam V.B.*
dc.author.googleRao K.S.*
dc.author.googleMohan A.V.N.*
dc.author.googlePark C.-Y.*
dc.author.googleSon J.-Y.*
dc.author.googleSheen Y.Y.*
dc.author.googleKim D.-K.*
dc.contributor.scopusid신윤용(6603872711)*
dc.contributor.scopusid김대기(35083694200)*
dc.date.modifydate20240118164500*
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약학대학 > 약학과 > Journal papers
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