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Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives

Title
Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives
Authors
Rhee H.-K.Yoo J.H.Lee E.Kwon Y.J.Seo H.-R.Lee Y.-S.Choo H.-Y.P.
Ewha Authors
박혜영권영주이윤실
SCOPUS Author ID
박혜영scopus; 권영주scopus; 이윤실scopus
Issue Date
2011
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 46, no. 9, pp. 3900 - 3908
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Thirty 2-phenylquinazolin-4(3H)-one derivatives were prepared and their cytotoxic activities were tested in five human tumor cell lines. Some compounds (5e, 5k, 5t, 6c and 6f) showed relatively high cytotoxic activity. Especially, compound 6c showed the most cytotoxicity against all cell lines tested among the synthesized derivatives, and the inhibitory activity of 6c against HeLa cell was higher than that of adriamycin. The putative mechanism of antitumor action in apoptotic cell death was cell cycle arrest in the G0/G1 phase by compounds 5k, 5v, 5m, 6c, and 6f in HeLa cells. These compounds showed relatively high cytotoxicity in this cell type. © 2011 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.ejmech.2011.05.061
Appears in Collections:
약학대학 > 약학과 > Journal papers
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