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Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives
- Title
- Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives
- Authors
- Rhee H.-K.; Yoo J.H.; Lee E.; Kwon Y.J.; Seo H.-R.; Lee Y.-S.; Choo H.-Y.P.
- Ewha Authors
- 박혜영; 권영주; 이윤실
- SCOPUS Author ID
- 박혜영; 권영주; 이윤실
- Issue Date
- 2011
- Journal Title
- European Journal of Medicinal Chemistry
- ISSN
- 0223-5234
- Citation
- European Journal of Medicinal Chemistry vol. 46, no. 9, pp. 3900 - 3908
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Thirty 2-phenylquinazolin-4(3H)-one derivatives were prepared and their cytotoxic activities were tested in five human tumor cell lines. Some compounds (5e, 5k, 5t, 6c and 6f) showed relatively high cytotoxic activity. Especially, compound 6c showed the most cytotoxicity against all cell lines tested among the synthesized derivatives, and the inhibitory activity of 6c against HeLa cell was higher than that of adriamycin. The putative mechanism of antitumor action in apoptotic cell death was cell cycle arrest in the G0/G1 phase by compounds 5k, 5v, 5m, 6c, and 6f in HeLa cells. These compounds showed relatively high cytotoxicity in this cell type. © 2011 Elsevier Masson SAS. All rights reserved.
- DOI
- 10.1016/j.ejmech.2011.05.061
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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