Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2016-08-28T12:08:14Z | - |
dc.date.available | 2016-08-28T12:08:14Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.other | OAK-7952 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221940 | - |
dc.description.abstract | On the basis of the chemical structures of psorospermin with a xanthone template and acronycine derivatives with an acridone template, rac-1 and rac-2 constructed on an 1,2-dihydrobenzofuro[4,5-b][1,8]naphthyridin-6(11H)-one scaffold were designed and synthesized as potential anticancer agents. Their anticancer activities were evaluated against five human cancer cell lines. Rac-2 showed similar anticancer activity to doxorubicin and rac-1 exhibited even higher anticancer activity against LNCaP (IC 50 = 0.14 μM), DU145 (IC 50 = 0.15 μM), PC3 (IC 50 = 0.30 μM) and MCF-7 (IC 50 = 0.26 μM) cancer lines than doxorubicin and rac-2. Also, rac-1 revealed very potent anticancer activity (IC 50 = 0.15 μM) against MCF-7/ADR cell (doxorubicin-resistant breast cancer cell) lines and induced G2/M phase arrest of the cell cycle in MCF-7/ADR cells. © 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b] [1,8]naphthyridin-6-one derivatives | - |
dc.type | Article | - |
dc.relation.issue | 19 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 5730 | - |
dc.relation.lastpage | 5734 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | - |
dc.identifier.doi | 10.1016/j.bmcl.2011.08.016 | - |
dc.identifier.wosid | WOS:000294714400014 | - |
dc.identifier.scopusid | 2-s2.0-80052566082 | - |
dc.author.google | Kang J.-A. | - |
dc.author.google | Yang Z. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | De U. | - |
dc.author.google | Kim T.H. | - |
dc.author.google | Park J.Y. | - |
dc.author.google | Lee H.J. | - |
dc.author.google | Park Y.J. | - |
dc.author.google | Chun P. | - |
dc.author.google | Kim H.S. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Moon H.R. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20211210153610 | - |