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Akt phosphorylates and regulates the osteogenic activity of Osterix

Title
Akt phosphorylates and regulates the osteogenic activity of Osterix
Authors
Choi Y.H.Jeong H.M.Jin Y.-H.Li H.Yeo C.-Y.Lee K.-Y.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2011
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 411, no. 3, pp. 637 - 641
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Osterix (Osx), a zinc-finger transcription factor is required for osteoblast differentiation and new bone formation during embryonic development. Akt is a member of the serine/threonine-specific protein kinase and plays important roles in osteoblast differentiation. The function of Osterix can be also modulated by post-translational modification. But, the precise molecular signaling mechanisms between Osterix and Akt are not known. In this study, we investigated the potential regulation of Osterix function by Akt in osteoblast differentiation. We found that Akt phosphorylates Osterix and that Akt activation increases protein stability, osteogenic activity and transcriptional activity of Osterix. We also found that BMP-2 increases the protein level of Osterix in an Akt activity-dependent manner. These results suggest that Akt activity enhances the osteogenic function of Osterix, at least in part, through protein stabilization and that BMP-2 regulates the osteogenic function of Osterix, at least in part, through Akt. © 2011 Elsevier Inc.
DOI
10.1016/j.bbrc.2011.07.009
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자연과학대학 > 생명과학전공 > Journal papers
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