Synthesis and biological activity of optically active phenylbutenoid dimers

Abstract

The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels-Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10. © 2011 The American Chemical Society and American Society of Pharmacognosy.