Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손형진 | * |
dc.contributor.author | 현동훈 | * |
dc.date.accessioned | 2016-08-28T12:08:09Z | - |
dc.date.available | 2016-08-28T12:08:09Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1567-7249 | * |
dc.identifier.other | OAK-7898 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221896 | - |
dc.description.abstract | The nature of mitochondrial dysfunction in dopaminergic neurons in familial Parkinson's disease (PD) is unknown. We characterized the pathophenotypes of dopaminergic neuronal cells that were deficient in PINK1 or DJ-1, genes with mutations linked to familial PD. Both PINK1- and DJ-1-deficient dopaminergic neurons had the increased production of ROS, severe mitochondrial structural damages and complex I deficits. A striking decrease in complex IV activity was also prominent by the PINK1-deficiency. The complex I deficits were relatively PD-specific and were significantly improved by an antioxidant Trolox. These data suggest that mitochondrial deficits are severe in dopaminergic neurons in familial PD and antioxidant-mediated functional recovery is feasible. © 2011. | * |
dc.language | English | * |
dc.title | The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 707 | * |
dc.relation.lastpage | 715 | * |
dc.relation.journaltitle | Mitochondrion | * |
dc.identifier.doi | 10.1016/j.mito.2011.05.013 | * |
dc.identifier.wosid | WOS:000294089000005 | * |
dc.identifier.scopusid | 2-s2.0-79961207215 | * |
dc.author.google | Shim J.H. | * |
dc.author.google | Yoon S.H. | * |
dc.author.google | Kim K.-H. | * |
dc.author.google | Han J.Y. | * |
dc.author.google | Ha J.-Y. | * |
dc.author.google | Hyun D.H. | * |
dc.author.google | Paek S.H. | * |
dc.author.google | Kang U.J. | * |
dc.author.google | Zhuang X. | * |
dc.author.google | Son J.H. | * |
dc.contributor.scopusid | 손형진(7203086503) | * |
dc.contributor.scopusid | 현동훈(7005049041) | * |
dc.date.modifydate | 20240123112641 | * |