Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 현동훈 | * |
dc.date.accessioned | 2016-08-28T12:08:08Z | - |
dc.date.available | 2016-08-28T12:08:08Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0921-9668 | * |
dc.identifier.other | OAK-7883 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221882 | - |
dc.description.abstract | This study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expr.occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis. © 2011 Springer Science+Business Media, LLC. | * |
dc.language | English | * |
dc.title | Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 66 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 101 | * |
dc.relation.lastpage | 106 | * |
dc.relation.journaltitle | Plant Foods for Human Nutrition | * |
dc.identifier.doi | 10.1007/s11130-011-0232-6 | * |
dc.identifier.wosid | WOS:000293978000002 | * |
dc.identifier.scopusid | 2-s2.0-79960243414 | * |
dc.author.google | Kang M.R. | * |
dc.author.google | Kim H.M. | * |
dc.author.google | Kang J.S. | * |
dc.author.google | Lee K. | * |
dc.author.google | Lee S.D. | * |
dc.author.google | Hyun D.-H. | * |
dc.author.google | In M.-J. | * |
dc.author.google | Park S.-K. | * |
dc.author.google | Kim D.C. | * |
dc.contributor.scopusid | 현동훈(7005049041) | * |
dc.date.modifydate | 20240123112641 | * |