View : 568 Download: 0
Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia
- Title
- Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia
- Authors
- Lee J.H.; Oh Y.-M.; Seo J.B.; Lee Y.K.; Kim W.J.; Sheen S.S.; Kim T.-H.; Lee J.-H.; Kim E.-K.; Lee J.S.; Huh J.W.; Lim S.Y.; Yoon H.I.; Shin T.R.; Lee S.-M.; Lee S.Y.; Lee S.-D.
- Ewha Authors
- 이진화
- SCOPUS Author ID
- 이진화
- Issue Date
- 2011
- Journal Title
- International Journal of Tuberculosis and Lung Disease
- ISSN
- 1027-3719
- Citation
- International Journal of Tuberculosis and Lung Disease vol. 15, no. 6, pp. 830 - 837+i
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- BACKGROUND: Chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension and cor pulmonale, which are predictors of mortality. OBJECTIVE: To identify predictors of increased pulmonary artery pressure (PAP) in COPD patients without resting hypoxaemia, and to characterise COPD patients with increased PAP. DESIGN: A study of 117 COPD patients from the Korean Obstructive Lung Disease (KOLD) cohort who had measurable tricuspid regurgitant flow under transthoracic Doppler echocardiography and no resting hypoxaemia. RESULTS: The mean patient age was 67 years. Mean forced expiratory volume in 1 second (FEV1) was 47% predicted, mean haemoglobin (Hb) concentration was 145 g/l and mean systolic PAP (sPAP) was 33 mmHg. Multiple linear regression analysis showed that Hb was the only factor independently associated with sPAP (beta = -1.752, P = 0.005). Cluster analysis using FEV 1% predicted, sPAP and Hb concentration as variables indicated three patient clusters: Cluster 1 (n = 36; mean FEV 1 44% predicted, mean sPAP 39 mmHg, mean Hb 132 g/l), Cluster 2 (n = 45; FEV 1 35% predicted, sPAP 31 mmHg, Hb 154 g/l), and Cluster 3 (n = 36; FEV 1 65% predicted, sPAP 29 mmHg, Hb 148 g/l). CONCLUSION: Elevated PAP was linked to low haemoglobin levels in COPD without resting hypoxaemia. © 2011 The Union.
- DOI
- 10.5588/ijtld.10.0598
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML