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Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia

Title
Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia
Authors
Lee J.H.Oh Y.-M.Seo J.B.Lee Y.K.Kim W.J.Sheen S.S.Kim T.-H.Lee J.-H.Kim E.-K.Lee J.S.Huh J.W.Lim S.Y.Yoon H.I.Shin T.R.Lee S.-M.Lee S.Y.Lee S.-D.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 15, no. 6, pp. 830 - 837+i
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension and cor pulmonale, which are predictors of mortality. OBJECTIVE: To identify predictors of increased pulmonary artery pressure (PAP) in COPD patients without resting hypoxaemia, and to characterise COPD patients with increased PAP. DESIGN: A study of 117 COPD patients from the Korean Obstructive Lung Disease (KOLD) cohort who had measurable tricuspid regurgitant flow under transthoracic Doppler echocardiography and no resting hypoxaemia. RESULTS: The mean patient age was 67 years. Mean forced expiratory volume in 1 second (FEV1) was 47% predicted, mean haemoglobin (Hb) concentration was 145 g/l and mean systolic PAP (sPAP) was 33 mmHg. Multiple linear regression analysis showed that Hb was the only factor independently associated with sPAP (beta = -1.752, P = 0.005). Cluster analysis using FEV 1% predicted, sPAP and Hb concentration as variables indicated three patient clusters: Cluster 1 (n = 36; mean FEV 1 44% predicted, mean sPAP 39 mmHg, mean Hb 132 g/l), Cluster 2 (n = 45; FEV 1 35% predicted, sPAP 31 mmHg, Hb 154 g/l), and Cluster 3 (n = 36; FEV 1 65% predicted, sPAP 29 mmHg, Hb 148 g/l). CONCLUSION: Elevated PAP was linked to low haemoglobin levels in COPD without resting hypoxaemia. © 2011 The Union.
DOI
10.5588/ijtld.10.0598
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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