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Different therapeutic responses in chronic obstructive pulmonary disease subgroups

Title
Different therapeutic responses in chronic obstructive pulmonary disease subgroups
Authors
Lee J.S.Huh J.W.Chae E.J.Seo J.B.Ra S.W.Lee J.-H.Kim E.-K.Lee Y.K.Kim T.-H.Kim W.J.Lee J.H.Lee S.-M.Lee S.Lim S.Y.Shin T.R.Yoon H.I.Sheen S.S.Oh Y.-M.Lee S.-D.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 15, no. 8, pp. 1104 - 1110
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment. © 2011 The Union.
DOI
10.5588/ijtld.10.0553
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의학전문대학원 > 의학과 > Journal papers
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