Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김화정 | * |
dc.contributor.author | 이경림 | * |
dc.contributor.author | 신동해 | * |
dc.date.accessioned | 2016-08-28T12:08:01Z | - |
dc.date.available | 2016-08-28T12:08:01Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0014-2999 | * |
dc.identifier.other | OAK-7804 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221811 | - |
dc.description.abstract | Previously, we have reported that a 10-amino acid peptide (MIIYRDLISH) derived from the NH2-terminus of the human translationally controlled tumor protein (TCTP) functions as a protein transduction domain (PTD). In this study, we evaluated the transduction ability of SOD fused to TCTP-PTD (TCTP-SOD) into various cell lines. We also evaluated its ability to protect cells against paraquat-induced cell damage, in vitro and its neuroprotective effect in vivo against kainic acid-induced neuronal damage in an animal model. TCTP-SOD was transduced into various cell lines in a dose- and time-dependent manner without cytotoxic effect. Furthermore, TCTP-SOD showed cytoprotective activity in SH-SY5Y cells, and intraperitoneally, injected TCTP-SOD was delivered into the mouse brain and protected the cells in the hippocampal region against the damage induced by kainic acid. We propose TCTP-SOD as a potential candidate drug for treatment of brain diseases. © 2011 Elsevier B.V. | * |
dc.language | English | * |
dc.title | Neuroprotective effect of Cu,Zn-superoxide dismutase fused to a TCTP-derived protein transduction domain | * |
dc.type | Article | * |
dc.relation.issue | 41277 | * |
dc.relation.volume | 666 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 87 | * |
dc.relation.lastpage | 92 | * |
dc.relation.journaltitle | European Journal of Pharmacology | * |
dc.identifier.doi | 10.1016/j.ejphar.2011.05.040 | * |
dc.identifier.wosid | WOS:000293050900012 | * |
dc.identifier.scopusid | 2-s2.0-79959964805 | * |
dc.author.google | Lee J. | * |
dc.author.google | Kim S. | * |
dc.author.google | Shin D.H. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.contributor.scopusid | 신동해(57217374185) | * |
dc.date.modifydate | 20240501081003 | * |