Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:00Z | - |
dc.date.available | 2016-08-28T12:08:00Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1744-683X | * |
dc.identifier.other | OAK-7801 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221808 | - |
dc.description.abstract | We are reporting triblock copolymers of (ethylene glycol) 44-(l-alanine) 9-(dl-alanine) 9 (PEG-l-PA-dl-PA) with α-helical l-PA localized between flexible PEG and dl-PA, and (ethylene glycol) 44-(dl-alanine) 9-(l-alanine) 9 (PEG-dl-PA-l-PA) with gradient flexibility in water. Aqueous solutions of PEG-l-PA-dl-PA underwent only sol-to-gel transition, whereas those of PEG-dl-PA-l-PA underwent sol-to-gel-to-squeezed gel transitions as the temperature increased. The l-PAs of both polymers have an α-helical secondary structure in water at low temperature. However, the α-helical structure of the PEG-dl-PA-l-PA changed into a random coil structure as the temperature increased above 40°C, whereas the PEG-l-PA-dl-PA kept the α-helical secondary structure over the same investigated temperature range of 4°C to 50°C. Cryo-transmission electron microscopy images and dynamic light scattering suggested that the PEG-l-PA-dl-PA develops spherical micelles, whereas the PEG-dl-PA-l-PA develops cylindrical bundles as well as spherical micelles in water. Even though both block copolymers have a similar composition of (ethylene glycol) 44, (l-alanine) 9, and (dl-alanine) 9, they showed significantly different temperature-sensitivities as well as different nano-assemblies in water. This report suggests that the block sequence of a polymer is very important in developing a specific nano-structure as well as in controlling thermosensitivity of the polymer, thus providing useful molecular information in designing a biomaterial. © 2011 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.title | Block sequence affects thermosensitivity and nano-assembly: PEG-l-PA-dl-PA and PEG-dl-PA-l-PA block copolymers | * |
dc.type | Article | * |
dc.relation.issue | 14 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6515 | * |
dc.relation.lastpage | 6521 | * |
dc.relation.journaltitle | Soft Matter | * |
dc.identifier.doi | 10.1039/c1sm05505d | * |
dc.identifier.wosid | WOS:000292985500020 | * |
dc.identifier.scopusid | 2-s2.0-79960162048 | * |
dc.author.google | Park S.H. | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Moon H.J. | * |
dc.author.google | Cho S.-H. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |