Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T12:08:59Z | - |
dc.date.available | 2016-08-28T12:08:59Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1529-2908 | * |
dc.identifier.other | OAK-7792 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221799 | - |
dc.description.abstract | The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxin-induced sepsis. SHP had dual regulatory functions in a canonical transcription factor NF-κB signaling pathway, acting as both a repressor of transactivation of the NF-κB subunit p65 and an inhibitor of polyubiquitination of the adaptor TRAF6. SHP-mediated inhibition of signaling via the TLR was mimicked by macrophage-stimulating protein (MSP), a strong inducer of SHP expression, via an AMP-activated protein kinase-dependent signaling pathway. Our data identify a previously unrecognized role for SHP in the regulation of TLR signaling. © 2011 Nature America, Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors | * |
dc.type | Review | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 742 | * |
dc.relation.lastpage | 751 | * |
dc.relation.journaltitle | Nature Immunology | * |
dc.identifier.doi | 10.1038/ni.2064 | * |
dc.identifier.wosid | WOS:000292870700012 | * |
dc.identifier.scopusid | 2-s2.0-80052020185 | * |
dc.author.google | Yuk J.-M. | * |
dc.author.google | Shin D.-M. | * |
dc.author.google | Lee H.-M. | * |
dc.author.google | Kim J.-J. | * |
dc.author.google | Kim S.-W. | * |
dc.author.google | Jin H.S. | * |
dc.author.google | Yang C.-S. | * |
dc.author.google | Park K.A. | * |
dc.author.google | Chanda D. | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Huang S.M. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Lee C.-H. | * |
dc.author.google | Kim J.-M. | * |
dc.author.google | Song C.-H. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Hur G.M. | * |
dc.author.google | Moore D.D. | * |
dc.author.google | Choi H.-S. | * |
dc.author.google | Jo E.-K. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |