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Pro-inflammatory cytokine expression of spleen dendritic cells in mouse toxoplasmosis

Title
Pro-inflammatory cytokine expression of spleen dendritic cells in mouse toxoplasmosis
Authors
Nam H.-W.Ahn H.-J.Yang H.-J.
Ewha Authors
양현종
SCOPUS Author ID
양현종scopus
Issue Date
2011
Journal Title
Korean Journal of Parasitology
ISSN
0023-4001JCR Link
Citation
vol. 49, no. 2, pp. 109 - 114
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8α +/ CD11c + splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis. © 2011, Korean Society for Parasitology.
DOI
10.3347/kjp.2011.49.2.109
Appears in Collections:
의과대학 > 의학과 > Journal papers
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