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SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2

Title
SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2
Authors
Kim H.J.Yun J.Lee J.Hong H.Jeong J.Kim E.Bae Y.S.Lee K.-J.
Ewha Authors
이공주배윤수김현정
SCOPUS Author ID
이공주scopus; 배윤수scopus
Issue Date
2011
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 410, no. 3, pp. 555 - 562
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation and its precise biological function is poorly understood. During our studies on heat-shock responses, we found that heat-shock stress increased SUMO1 conjugation in a dose-dependent manner. Intriguingly, SUMO1 conjugation resulted in decrease of intracellular ROS generation and protection cells from death under heat-shock stress. We showed that NADPH oxidase 2 (NOX2) is a target protein of sumoylation by SUMO1 using immunoprecipitation and is colocalized with SUMO1 at plasma membrane. Additionally, we demonstrated that the attenuation in intracellular ROS generation resulted from inhibition of NADPH oxidase complex (NOX) activity. These results suggested that SUMO1 plays an important role in modulation of NOX activity required for ROS generation. © 2011 Elsevier Inc.
DOI
10.1016/j.bbrc.2011.06.025
Appears in Collections:
약학대학 > 약학과 > Journal papers
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