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Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H 2O 2, and protein chaperones

Title
Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H 2O 2, and protein chaperones
Authors
Rhee S.G.Woo H.A.
Ewha Authors
이서구우현애
SCOPUS Author ID
이서구scopusscopus; 우현애scopus
Issue Date
2011
Journal Title
Antioxidants and Redox Signaling
ISSN
1523-0864JCR Link
Citation
vol. 15, no. 3, pp. 781 - 794
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C R]) to form a disulfide that is subsequently reduced by an appropriate electron donor. On the basis of the location or absence of the C R, Prxs are classified into 2-Cys, atypical 2-Cys, and 1-Cys Prx subfamilies. In addition to their peroxidase activity, members of the 2-Cys Prx subfamily appear to serve as peroxide sensors for other proteins and as molecular chaperones. During catalysis, the peroxidatic Cys-SOH of 2-Cys Prxs is occasionally further oxidized to Cys-SO 2H before disulfide formation, resulting in inactivation of peroxidase activity. This hyperoxidation, which is reversed by the ATP-dependent enzyme sulfiredoxin, modulates the sensor and chaperone functions of 2-Cys Prxs. The peroxidase activity of 2-Cys Prxs is extensively regulated via tyrosine and threonine phosphorylation, which allows modulation of the local concentration of the intracellular messenger H 2O 2. Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner. © 2011 Mary Ann Liebert, Inc.
DOI
10.1089/ars.2010.3393
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일반대학원 > 생명·약학부 > Journal papers
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