View : 49 Download: 0
Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H 2O 2, and protein chaperones
- Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H 2O 2, and protein chaperones
- Rhee S.G.; Woo H.A.
- Ewha Authors
- 이서구; 우현애
- SCOPUS Author ID
- 이서구; 우현애
- Issue Date
- Journal Title
- Antioxidants and Redox Signaling
- vol. 15, no. 3, pp. 781 - 794
- SCI; SCIE; SCOPUS
- Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C R]) to form a disulfide that is subsequently reduced by an appropriate electron donor. On the basis of the location or absence of the C R, Prxs are classified into 2-Cys, atypical 2-Cys, and 1-Cys Prx subfamilies. In addition to their peroxidase activity, members of the 2-Cys Prx subfamily appear to serve as peroxide sensors for other proteins and as molecular chaperones. During catalysis, the peroxidatic Cys-SOH of 2-Cys Prxs is occasionally further oxidized to Cys-SO 2H before disulfide formation, resulting in inactivation of peroxidase activity. This hyperoxidation, which is reversed by the ATP-dependent enzyme sulfiredoxin, modulates the sensor and chaperone functions of 2-Cys Prxs. The peroxidase activity of 2-Cys Prxs is extensively regulated via tyrosine and threonine phosphorylation, which allows modulation of the local concentration of the intracellular messenger H 2O 2. Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner. © 2011 Mary Ann Liebert, Inc.
- Appears in Collections:
- 일반대학원 > 생명·약학부 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.