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dc.contributor.author이서구*
dc.contributor.author우현애*
dc.date.accessioned2016-08-28T12:08:56Z-
dc.date.available2016-08-28T12:08:56Z-
dc.date.issued2011*
dc.identifier.issn1523-0864*
dc.identifier.otherOAK-7761*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221773-
dc.description.abstractPeroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C R]) to form a disulfide that is subsequently reduced by an appropriate electron donor. On the basis of the location or absence of the C R, Prxs are classified into 2-Cys, atypical 2-Cys, and 1-Cys Prx subfamilies. In addition to their peroxidase activity, members of the 2-Cys Prx subfamily appear to serve as peroxide sensors for other proteins and as molecular chaperones. During catalysis, the peroxidatic Cys-SOH of 2-Cys Prxs is occasionally further oxidized to Cys-SO 2H before disulfide formation, resulting in inactivation of peroxidase activity. This hyperoxidation, which is reversed by the ATP-dependent enzyme sulfiredoxin, modulates the sensor and chaperone functions of 2-Cys Prxs. The peroxidase activity of 2-Cys Prxs is extensively regulated via tyrosine and threonine phosphorylation, which allows modulation of the local concentration of the intracellular messenger H 2O 2. Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner. © 2011 Mary Ann Liebert, Inc.*
dc.languageEnglish*
dc.titleMultiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H 2O 2, and protein chaperones*
dc.typeReview*
dc.relation.issue3*
dc.relation.volume15*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage781*
dc.relation.lastpage794*
dc.relation.journaltitleAntioxidants and Redox Signaling*
dc.identifier.doi10.1089/ars.2010.3393*
dc.identifier.wosidWOS:000292446300012*
dc.identifier.scopusid2-s2.0-79951643450*
dc.author.googleRhee S.G.*
dc.author.googleWoo H.A.*
dc.contributor.scopusid이서구(7401852092)*
dc.contributor.scopusid우현애(8068619500)*
dc.date.modifydate20240215164922*
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일반대학원 > 생명·약학부 > Journal papers
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