Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경림 | * |
dc.contributor.author | 신동해 | * |
dc.date.accessioned | 2016-08-28T12:08:51Z | - |
dc.date.available | 2016-08-28T12:08:51Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0142-9612 | * |
dc.identifier.other | OAK-7705 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221725 | - |
dc.description.abstract | We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH2-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its proapoptotic activity to inhibit tumor growth. We evaluated the cellular uptake of KLA fused to TCTP-PTD (hereafter called TCTP-KLA) and its effect on cancer cell viability. The IC50 of TCTP-KLA was between 7 and 10 μmol/L. We also evaluated its anti-tumor activity in vivo by injecting it into xenografts of lung carcinoma in Balb/c nude mice. Tumor growth inhibition resulting from treatment with TCTP-KLA was better than that of TAT-KLA. These results suggest that TCTP-KLA can be applied to design cancer therapeutics. © 2011 Elsevier Ltd. | * |
dc.language | English | * |
dc.title | The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH | * |
dc.type | Article | * |
dc.relation.issue | 22 | * |
dc.relation.volume | 32 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5262 | * |
dc.relation.lastpage | 5268 | * |
dc.relation.journaltitle | Biomaterials | * |
dc.identifier.doi | 10.1016/j.biomaterials.2011.03.074 | * |
dc.identifier.wosid | WOS:000291900700029 | * |
dc.identifier.scopusid | 2-s2.0-79956076191 | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Kim S. | * |
dc.author.google | Youn H. | * |
dc.author.google | Chung J.-K. | * |
dc.author.google | Shin D.H. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.contributor.scopusid | 신동해(57217374185) | * |
dc.date.modifydate | 20240301081003 | * |