Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오억수 | - |
dc.date.accessioned | 2016-08-28T12:08:48Z | - |
dc.date.available | 2016-08-28T12:08:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-7670 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221698 | - |
dc.description.abstract | The cell surface heparan sulfate proteoglycan, syndecan-2, is crucial for the tumorigenic activity of colon cancer cells. However, the role played by the cytoplasmic domain of the protein remains unclear. Using colon cancer cells transfected with various syndecan-2-encoding genes with deletions in the cytoplasmic domain, it was shown that syndecan-2-induced migration activity requires the EFYA sequence of the C-terminal region; deletion of these residues abolished the rise in cell migration seen when the wild-type gene was transfected and syndecan-2 interaction with syntenin-1, suggesting that syntenin-1 functioned as a cytosolic signal effector downstream from syndecan-2. Colon cancer cells transfected with the syntenin-1 gene showed increased migratory activity, whereas migration was decreased in cells in which syntenin-1 was knock-down using small inhibitory RNA. In addition, syntenin-1 expression potentiated colon cancer cell migration induced by syndecan-2, and syndecan-2-mediated cell migration was reduced when syntenin-1 expression diminished. However, syntenin-1-mediated migration enhancement was not noted in colon cancer cells transfected with a gene encoding a syndecan-2 mutant lacking the cytoplasmic domain. Furthermore, in line with the increase in cell migration, syntenin-1 mediated Rac activation stimulated by syndecan-2. Together, the data suggest that the cytoplasmic domain of syndecan-2 regulates colon cancer cell migration via interaction with syntenin-1. © 2011 Elsevier Inc. | - |
dc.language | English | - |
dc.title | Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1 | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 409 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 148 | - |
dc.relation.lastpage | 153 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.04.135 | - |
dc.identifier.wosid | WOS:000291380100025 | - |
dc.identifier.scopusid | 2-s2.0-79956194358 | - |
dc.author.google | Lee H. | - |
dc.author.google | Kim Y. | - |
dc.author.google | Choi Y. | - |
dc.author.google | Choi S. | - |
dc.author.google | Hong E. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20190901081003 | - |