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Disturbed flow: P53 SUMOylation in the turnover of endothelial cells

Title
Disturbed flow: P53 SUMOylation in the turnover of endothelial cells
Authors
Takabe W.Alberts-Grill N.Jo H.
Ewha Authors
조한중
Issue Date
2011
Journal Title
Journal of Cell Biology
ISSN
0021-9525JCR Link
Citation
vol. 193, no. 5, pp. 805 - 807
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53's role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it's binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis. © 2011 Takabe et al.
DOI
10.1083/jcb.201104140
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일반대학원 > 바이오융합과학과 > Journal papers
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