Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조한중 | - |
dc.date.accessioned | 2016-08-28T12:08:45Z | - |
dc.date.available | 2016-08-28T12:08:45Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.other | OAK-7641 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221675 | - |
dc.description.abstract | Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53's role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it's binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis. © 2011 Takabe et al. | - |
dc.language | English | - |
dc.title | Disturbed flow: P53 SUMOylation in the turnover of endothelial cells | - |
dc.type | Note | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 193 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 805 | - |
dc.relation.lastpage | 807 | - |
dc.relation.journaltitle | Journal of Cell Biology | - |
dc.identifier.doi | 10.1083/jcb.201104140 | - |
dc.identifier.wosid | WOS:000291049000003 | - |
dc.identifier.scopusid | 2-s2.0-79959487348 | - |
dc.author.google | Takabe W. | - |
dc.author.google | Alberts-Grill N. | - |
dc.author.google | Jo H. | - |
dc.date.modifydate | 20160429000000 | - |