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Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with 1H-NMR based metabolic profiling

Title
Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with 1H-NMR based metabolic profiling
Authors
Kim S.-H.Cho S.K.Min T.-S.Kim Y.Yang S.-O.Kim H.-S.Hyun S.-H.Kim H.Kim Y.-S.Choi H.-K.
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2011
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
0912-0009JCR Link
Citation
vol. 48, no. 3, pp. 214 - 221
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The ameliorating effects of Mango (Mangifera indica L.) flesh and peel samples on plasma ethanol level were investigated using a mouse model. Mango fruit samples remarkably decreased mouse plasma ethanol levels and increased the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. The 1H-NMR-based metabolomic technique was employed to investigate the differences in metabolic profiles of mango fruits, and mouse plasma samples fed with mango fruit samples. The partial least squares-discriminate analysis of 1H-NMR spectral data of mouse plasma demonstrated that there were clear separations among plasma samples from mice fed with buffer, mango flesh and peel. A loading plot demonstrated that metabolites from mango fruit, such as fructose and aspartate, might stimulate alcohol degradation enzymes. This study suggests that mango flesh and peel could be used as resources for functional foods intended to decrease plasma ethanol level after ethanol uptake. ©2011 JCBN.
DOI
10.3164/jcbn.10-96
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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