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Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

Title
Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme
Authors
Lee H.W.Nam S.K.Choi W.J.Kim H.O.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2011
Journal Title
Journal of Organic Chemistry
ISSN
0022-3263JCR Link
Citation
vol. 76, no. 9, pp. 3557 - 3561
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps. © 2011 American Chemical Society.
DOI
10.1021/jo2001897
Appears in Collections:
약학대학 > 약학과 > Journal papers
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