Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 손형진 | - |
dc.date.accessioned | 2016-08-28T12:08:36Z | - |
dc.date.available | 2016-08-28T12:08:36Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.other | OAK-7545 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221595 | - |
dc.description.abstract | There are two causes of Parkinson's disease (PD): environmental insults and genetic mutations of PD-associated genes. Environmental insults and genetic mutations lead to mitochondrial dysfunction, and a combination of mitochondrial dysfunction and increased oxidative stress in dopaminergic neurons is thought to contribute to the pathogenesis of PD. Among the PD-associated genes, DJ-1 acts as a redox sensor for oxidative stress and has been also proposed to maintain mitochondrial complex I activity. To understand molecular functions of DJ-1 in the cell, we have generated DJ-1 null cells from the DJ-1(-/-) mouse embryos. Using these null cells, we investigated the susceptibility to an environmental toxin, paraquat, which is known to inhibit mitochondrial complex I. Interestingly, we found that DJ-1 null cells showed a resistance to paraquat-induced apoptosis, including reduced poly (ADP-ribose) polymerase and procaspase-3. Also DJ-1 null cells generated less superoxide than SN4741 cells by paraquat treatment. Consistent with the reduced paraquat sensitivity, DJ-1 null cells showed reduced complex I activity, which was partially rescued by ectopic DJ-I expression. In summary, our results suggest that DJ-1 is critical to maintain mitochondrial complex I and complex I could be a key target in interaction of paraquat toxicity and DJ-1 for giving rise to PD. © 2011 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 202 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 85 | - |
dc.relation.lastpage | 92 | - |
dc.relation.journaltitle | Toxicology Letters | - |
dc.identifier.doi | 10.1016/j.toxlet.2011.01.018 | - |
dc.identifier.wosid | WOS:000289708000002 | - |
dc.identifier.scopusid | 2-s2.0-79952618692 | - |
dc.author.google | Kwon H.J. | - |
dc.author.google | Heo J.Y. | - |
dc.author.google | Shim J.H. | - |
dc.author.google | Park J.H. | - |
dc.author.google | Seo K.S. | - |
dc.author.google | Ryu M.J. | - |
dc.author.google | Han J.S. | - |
dc.author.google | Shong M. | - |
dc.author.google | Son J.H. | - |
dc.author.google | Kweon G.R. | - |
dc.contributor.scopusid | 손형진(7203086503) | - |
dc.date.modifydate | 20220119162545 | - |