Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:32Z | - |
dc.date.available | 2016-08-28T12:08:32Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1525-7797 | * |
dc.identifier.other | OAK-7493 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221556 | - |
dc.description.abstract | In the search for an enzymatically degradable thermogelling system, we are reporting poly(alanine-co-leucine)-poloxamer-poly(alanine-co-leucine) (PAL-PLX-PAL) aqueous solution. As the temperature increased, the polymer aqueous solution underwent sol-to-gel transition at 20-40 °C in a polymer concentration range of 3.0-10.0 wt %. The amphiphilic polymers of PAL-PLX-PAL form micelles in water, where the hydrophobic PALs form a core and the hydrophilic PLXs form a shell of the micelle. FTIR, circular dichroism, and 13C NMR spectra suggest that the -helical secondary structure of PAL is preserved; however, the molecular motion of the PLX significantly decreases in the sol-to-gel transition range of 20-50 °C. The polymer was degraded by proteolytic enzymes such as matrix metalloproteinase and elastase, whereas it was quite stable against cathepsin B, cathepsin C, and chymotrypsin or in phosphate-buffered saline (control). The in situ formed gel in the subcutaneous layer of rats showed a duration of 47 days, and H&E staining study suggests the histocompatibility of the gel in vivo with a marginal inflammation response of capsule formation. A model drug of bovine serum albumin was released over 1 month by the preset-gel injection method. The thermogelling PAL-PLX-PAL can be a promising biocompatible material for minimally invasive injectable drug delivery. © 2011 American Chemical Society. | * |
dc.language | English | * |
dc.title | Enzymatically degradable thermogelling poly(alanine-co-leucine)-poloxamer- poly(alanine-co-leucine) | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1234 | * |
dc.relation.lastpage | 1242 | * |
dc.relation.journaltitle | Biomacromolecules | * |
dc.identifier.doi | 10.1021/bm101518c | * |
dc.identifier.wosid | WOS:000289223500043 | * |
dc.identifier.scopusid | 2-s2.0-79953907412 | * |
dc.author.google | Moon H.J. | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Joo M.K. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |