A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production

Abstract

A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity. © 2011 The Royal Society of Chemistry.