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Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues

Title
Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues
Authors
Sapkota K.Roh E.Lee E.Ha E.-M.Yang J.-H.Lee E.-S.Kwon Y.Kim Y.Na Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2011
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 19, no. 7, pp. 2168 - 2175
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to develop potent skin whitening agents, we have synthesized 17 hydroxyphenyl benzyl ether compounds and tested their melanin synthesis inhibitory activity, DPPH free radical scavenging activity and tyrosinase inhibitory activity. Compounds 32, 35 and 36 possessing 4-hydroxyphenyl benzyl ether structure showed excellent inhibitory capacity with almost 50-fold than arbutin used as a reference in the inhibition test of α-MSH stimulated melanin synthesis in B-16 cells. 4-Hydroxyphenyl benzyl ether compounds also showed good antioxidant activity in the DPPH free radical scavenging test. The tyrosinase function was effectively inhibited by 3,5-dihydroxyphenyl benzyl ether analogues, especially compounds 18, 22, and 24. © 2011 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2011.02.044
Appears in Collections:
약학대학 > 약학과 > Journal papers
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