Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:26Z | - |
dc.date.available | 2016-08-28T12:08:26Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0959-9428 | * |
dc.identifier.other | OAK-7435 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221505 | - |
dc.description.abstract | As a new thermal gelling polymer aqueous solution, we are reporting a poly(ethylene glycol)-poly(alanine) grafted chitosan (CS-g-(PA-PEG)) system. The sol-gel transition temperature and the modulus of the in situ-formed thermal gel at 37°C changed 17 → 27 →32°C and 396 → 241 → 43 Pa, respectively, as the pH increased from 3.0 to 6.5 and to 9.0. The mechanism of such a pH/temperature sensitive behaviour of the CS-g-(PA-PEG) aqueous solution was investigated by studying changes in the conformation of chitosan, polyalanine and PEG of the CS-g-(PA-PEG). As the temperature increased, ammonium groups of the chitosan partially deprotonated to a neutral form, the α-helical content of the polyalanine increased and molecular motion of the PEG decreased. Such changes cooperatively increase the hydrophobicity and viscosity of CS-g-(PA-PEG), resulting in the sol-gel transition of the polymer aqueous solution with increasing temperature. As the pH increased, ammonium groups of the chitosan deprotonated to a neutral form and the α-helical content of polyalanine decreased, which induce a change in the nanoassembly of the polymer. CS-g-(PA-PEG) significantly increased the gel modulus of a previously reported PEG grafted chitosan (CS-g-PEG) thermal gel by incorporating the α-helical polyalanine moieties between CS and PEG. The CS-g-(PA-PEG) could be a promising biomaterial as a new robust thermogel with pH and temperature sensitivity. © 2011 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.title | PH/temperature sensitive chitosan-g-(PA-PEG) aqueous solutions as new thermogelling systems | * |
dc.type | Article | * |
dc.relation.issue | 14 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5484 | * |
dc.relation.lastpage | 5491 | * |
dc.relation.journaltitle | Journal of Materials Chemistry | * |
dc.identifier.doi | 10.1039/c0jm03894f | * |
dc.identifier.wosid | WOS:000288659500041 | * |
dc.identifier.scopusid | 2-s2.0-79954605538 | * |
dc.author.google | Jang J.H. | * |
dc.author.google | Choi Y.M. | * |
dc.author.google | Choi Y.Y. | * |
dc.author.google | Joo M.K. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Kang E.Y. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |