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Rhodamine hydrazone derivatives as Hg2+ selective fluorescent and colorimetric chemosensors and their applications to bioimaging and microfluidic system

Title
Rhodamine hydrazone derivatives as Hg2+ selective fluorescent and colorimetric chemosensors and their applications to bioimaging and microfluidic system
Authors
Kim H.N.Nam S.-W.Swamy K.M.K.Jin Y.Chen X.Kim Y.Kim S.-J.Park S.Yoon J.
Ewha Authors
김성진김영미윤주영박성수K.M.K.Swamy
SCOPUS Author ID
김성진scopus; 김영미scopus; 윤주영scopus
Issue Date
2011
Journal Title
Analyst
ISSN
0003-2654JCR Link
Citation
vol. 136, no. 7, pp. 1339 - 1343
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In this paper, we report new rhodamine hydrazone derivatives bearing thiol and carboxylic acid groups as selective fluorescent and colorimetric chemosensors for Hg2+. The ring-opening process of spirolactam enables the large fluorescent enhancement and colorimetric change upon the addition of Hg2+. The sample containing Hg2+ was mixed with one of the chemosensors in a microchannel where the sensor was examined using confocal laser scanning microscopy. A plot of the fluorescent intensities of both chemosensors versus the log concentration of Hg2+ exhibited a linear response (r2 = 0.95) in the range of 1 nM-1 μM, and the detection limits were 1 nM and 4.2 nM, respectively. Both chemosensors also enable the visualization of Hg2+ accumulated in the nematode Caenorhabditis elegans previously exposed to nanomolar concentrations of Hg 2+. © The Royal Society of Chemistry 2011.
DOI
10.1039/c0an00804d
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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