DSpace at EWHA: Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production

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DC Field	Value	Language
dc.contributor.author	류재상	*
dc.date.accessioned	2016-08-28T12:08:24Z	-
dc.date.available	2016-08-28T12:08:24Z	-
dc.date.issued	2011	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-7412	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/221483	-
dc.description.abstract	A 28-membered 1,2,3-triazolyl salicylamide library was synthesized via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition and evaluated for their abilities to inhibit NO production in LPS-activated RAW264.7 macrophage cells. Among 28 analogues, 29g showed a significant inhibitory activity (IC 50 = 12.8 μM). The inhibitory effects of 29g on LPS-mediated NO production in macrophage cells appeared to be associated with the suppression of iNOS expression. © 2011 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production	*
dc.type	Article	*
dc.relation.issue	7	*
dc.relation.volume	21	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	1953	*
dc.relation.lastpage	1957	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2011.02.034	*
dc.identifier.wosid	WOS:000288245100009	*
dc.identifier.scopusid	2-s2.0-79952489956	*
dc.author.google	Yoon J.	*
dc.author.google	Cho L.	*
dc.author.google	Lee S.K.	*
dc.author.google	Ryu J.-S.	*
dc.contributor.scopusid	류재상(36081118200)	*
dc.date.modifydate	20231120165709	*