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Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins

Title
Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins
Authors
Lee K.-Y.Kim B.C.Han N.-K.Lee Y.-S.Kim T.Yun J.-H.Kim N.Pack J.-K.Lee J.-S.
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2011
Journal Title
Bioelectromagnetics
ISSN
0197-8462JCR Link
Citation
vol. 32, no. 3, pp. 169 - 178
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837MHz) or combined (837 and 1950MHz) RF radiation was conducted at specific absorption rate values of 4W/kg for 1h. During the exposure period, the chamber was made isothermal by circulating water through the cavity. After RF radiation exposure, DNA synthesis rate and cell cycle distribution were assessed. The levels of cell cycle regulatory proteins, p53, p21, cyclins, and cyclin-dependent kinases were also examined. The positive control group was exposed to 0.5 and 4Gy doses of ionizing radiation (IR) and showed changes in DNA synthesis and cell cycle distribution. The levels of p53, p21, cyclin A, cyclin B1, and cyclin D1 were also affected by IR exposure. In contrast to the IR-exposed group, neither the single RF radiation- nor the combined RF radiation-exposed group elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These results indicate that neither single nor combined RF radiation affect cell cycle progression. © 2010 Wiley-Liss, Inc.
DOI
10.1002/bem.20618
Appears in Collections:
약학대학 > 약학과 > Journal papers
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