Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강상원 | * |
dc.contributor.author | 권종범 | * |
dc.contributor.author | 이두재 | * |
dc.date.accessioned | 2016-08-28T12:08:21Z | - |
dc.date.available | 2016-08-28T12:08:21Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0021-9258 | * |
dc.identifier.other | OAK-7386 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221458 | - |
dc.description.abstract | The 2-Cys peroxiredoxins (Prx) belong to a family of antioxidant enzymes that detoxify reactive oxygen and nitrogen species and are distributed throughout the intracellular and extracellular compartments. However, the presence and role of 2-Cys Prxs in the nucleus have not been studied. This study demonstrates that the PrxII located in the nucleus protects cancer cells from DNA damage-induced cell death. Although the two cytosolic 2-Cys Prxs, PrxI and PrxII, were found in the nucleus, only PrxII knockdown selectively and markedly increased cell death in the cancer cells treated with DNA-damaging agents. The increased death was completely reverted by the nuclearly targeted expression of PrxII in an activity-independent manner. Furthermore, the antioxidant butylated hydroxyanisole did not influence the etoposide-induced cell death. Mechanistically, the knockdown of Prx II expression impaired the DNA repair process by reducing the activation of the JNK/c-Jun pathway. These results suggest that PrxII is likely to be attributed to a tumor survival factor positively regulating JNK-dependent DNA repair with its inhibition possibly sensitizing cancer cells to chemotherapeutic agents. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. | * |
dc.language | English | * |
dc.title | Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 286 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 8394 | * |
dc.relation.lastpage | 8404 | * |
dc.relation.journaltitle | Journal of Biological Chemistry | * |
dc.identifier.doi | 10.1074/jbc.M110.179416 | * |
dc.identifier.wosid | WOS:000288013300068 | * |
dc.identifier.scopusid | 2-s2.0-79953158615 | * |
dc.author.google | Lee K.W. | * |
dc.author.google | Lee D.J. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Kang D.H. | * |
dc.author.google | Kwon J. | * |
dc.author.google | Kang S.W. | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 권종범(7202469069) | * |
dc.contributor.scopusid | 이두재(26652094200) | * |
dc.date.modifydate | 20240426141057 | * |