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dc.contributor.author강상원-
dc.contributor.author권종범-
dc.contributor.author이두재-
dc.date.accessioned2017-08-28T21:35:40Z-
dc.date.available2017-08-28T21:35:40Z-
dc.date.issued2011-
dc.identifier.issn0021-9258-
dc.identifier.otherOAK-7386-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221458-
dc.description.abstractThe 2-Cys peroxiredoxins (Prx) belong to a family of antioxidant enzymes that detoxify reactive oxygen and nitrogen species and are distributed throughout the intracellular and extracellular compartments. However, the presence and role of 2-Cys Prxs in the nucleus have not been studied. This study demonstrates that the PrxII located in the nucleus protects cancer cells from DNA damage-induced cell death. Although the two cytosolic 2-Cys Prxs, PrxI and PrxII, were found in the nucleus, only PrxII knockdown selectively and markedly increased cell death in the cancer cells treated with DNA-damaging agents. The increased death was completely reverted by the nuclearly targeted expression of PrxII in an activity-independent manner. Furthermore, the antioxidant butylated hydroxyanisole did not influence the etoposide-induced cell death. Mechanistically, the knockdown of Prx II expression impaired the DNA repair process by reducing the activation of the JNK/c-Jun pathway. These results suggest that PrxII is likely to be attributed to a tumor survival factor positively regulating JNK-dependent DNA repair with its inhibition possibly sensitizing cancer cells to chemotherapeutic agents. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.-
dc.languageEnglish-
dc.titlePeroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume286-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage8394-
dc.relation.lastpage8404-
dc.relation.journaltitleJournal of Biological Chemistry-
dc.identifier.doi10.1074/jbc.M110.179416-
dc.identifier.wosidWOS:000288013300068-
dc.identifier.scopusid2-s2.0-79953158615-
dc.author.googleLee K.W.-
dc.author.googleLee D.J.-
dc.author.googleLee J.Y.-
dc.author.googleKang D.H.-
dc.author.googleKwon J.-
dc.author.googleKang S.W.-
dc.contributor.scopusid강상원(55731433900)-
dc.contributor.scopusid권종범(7202469069)-
dc.contributor.scopusid이두재(26652094200)-
dc.date.modifydate20180307081004-


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