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Total fatty acid content of the plasma membrane of Saccharomyces cerevisiae is more responsible for ethanol tolerance than the degree of unsaturation

Title
Total fatty acid content of the plasma membrane of Saccharomyces cerevisiae is more responsible for ethanol tolerance than the degree of unsaturation
Authors
Kim H.-S.Kim N.-R.Choi W.
Ewha Authors
최원자김현수
SCOPUS Author ID
최원자scopus
Issue Date
2011
Journal Title
Biotechnology Letters
ISSN
0141-5492JCR Link
Citation
vol. 33, no. 3, pp. 509 - 515
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effect of change in unsaturated fatty acid composition on ethanol tolerance in Saccharomyces cerevisiae overexpressing ScOLE1 (Δ9 fatty acid desaturase gene of S. cerevisiae), CaFAD2 (Δ12 fatty acid desaturase gene of Candida albicans), or CaFAD3 (ω3 fatty acid desaturase gene of C. albicans) was examined. ScOLE1 over-expression increased the total unsaturated fatty acid content and enhanced ethanol tolerance, compared with a control strain. In contrast, overexpression of CaFAD2 and CaFAD3, which led to production of linoleic acid (18:2) and α-linolenic acid (18:3), respectively, neither changed total unsaturated fatty acids nor enhanced ethanol tolerance. The total unsaturated fatty acid content rather than the degree of unsaturation is thus an important factor for ethanol tolerance. © 2010 Springer Science+Business Media B.V.
DOI
10.1007/s10529-010-0465-8
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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