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Nasopharyngeal pneumococcal carriage of children attending day care centers in Korea: Comparison between children immunized with 7-valent pneumococcal conjugate vaccine and non-immunized
- Title
- Nasopharyngeal pneumococcal carriage of children attending day care centers in Korea: Comparison between children immunized with 7-valent pneumococcal conjugate vaccine and non-immunized
- Authors
- Kim K.-H.; Hong J.Y.; Lee H.; Kwak G.Y.; Nam C.H.; Lee S.Y.; Oh E.; Yu J.; Nahm M.H.; Kang J.H.
- Ewha Authors
- 김경효
- SCOPUS Author ID
- 김경효
- Issue Date
- 2011
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Citation
- Journal of Korean Medical Science vol. 26, no. 2, pp. 184 - 190
- Indexed
- SCI; SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated children. Vaccinated subjects were recruited from highly vaccinated regions (≥ 60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 children aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non-vaccine type 16.7% (6/36) and vaccine type (VT) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were VT. Resistance rates for penicillin and erythromycin were lower in the vaccine group (vaccine vs control; penicillin 45.2% vs 71.4%, erythromycin 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in VT which leads to replacement of pneumococci by antibiotic susceptible VRT or non-vaccine type strains. © 2011 The Korean Academy of Medical Sciences.
- DOI
- 10.3346/jkms.2011.26.2.184
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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