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Nasopharyngeal pneumococcal carriage of children attending day care centers in Korea: Comparison between children immunized with 7-valent pneumococcal conjugate vaccine and non-immunized

Title
Nasopharyngeal pneumococcal carriage of children attending day care centers in Korea: Comparison between children immunized with 7-valent pneumococcal conjugate vaccine and non-immunized
Authors
Kim K.-H.Hong J.Y.Lee H.Kwak G.Y.Nam C.H.Lee S.Y.Oh E.Yu J.Nahm M.H.Kang J.H.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2011
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 26, no. 2, pp. 184 - 190
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated children. Vaccinated subjects were recruited from highly vaccinated regions (≥ 60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 children aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non-vaccine type 16.7% (6/36) and vaccine type (VT) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were VT. Resistance rates for penicillin and erythromycin were lower in the vaccine group (vaccine vs control; penicillin 45.2% vs 71.4%, erythromycin 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in VT which leads to replacement of pneumococci by antibiotic susceptible VRT or non-vaccine type strains. © 2011 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2011.26.2.184
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의학전문대학원 > 의학과 > Journal papers
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