DSpace at EWHA: Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors

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DC Field	Value	Language
dc.contributor.author	박혜영	-
dc.date.accessioned	2016-08-28T12:08:46Z	-
dc.date.available	2016-08-28T12:08:46Z	-
dc.date.issued	2010	-
dc.identifier.issn	0968-0896	-
dc.identifier.other	OAK-6973	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/221100	-
dc.description.abstract	5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC 50 value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness. © 2010 Elsevier Ltd. All rights reserved.	-
dc.language	English	-
dc.title	Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors	-
dc.type	Article	-
dc.relation.issue	21	-
dc.relation.volume	18	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	7580	-
dc.relation.lastpage	7585	-
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry	-
dc.identifier.doi	10.1016/j.bmc.2010.08.047	-
dc.identifier.wosid	WOS:000282904200024	-
dc.identifier.scopusid	2-s2.0-77957987009	-
dc.author.google	Song H.	-
dc.author.google	Oh S.-R.	-
dc.author.google	Lee H.-K.	-
dc.author.google	Han G.	-
dc.author.google	Kim J.-H.	-
dc.author.google	Chang H.W.	-
dc.author.google	Doh K.-E.	-
dc.author.google	Rhee H.-K.	-
dc.author.google	Choo H.-Y.P.	-
dc.contributor.scopusid	박혜영(34972649500;57200273796)	-
dc.date.modifydate	20230411110509	-