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Synthesis and biological properties of benzo-annulated rutaecarpines

Title
Synthesis and biological properties of benzo-annulated rutaecarpines
Authors
Hong Y.H.Lee W.J.Lee S.H.Son J.K.Kim H.L.Nam J.M.Kwon Y.Jahng Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2010
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
vol. 33, no. 10, pp. 1704 - 1709
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2- carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not directly related to the inhibitory activity against topoisomerases (topo) I and II. Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I. © 2010 Pharmaceutical Society of Japan.
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약학대학 > 약학과 > Journal papers
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