Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | * |
dc.contributor.author | 최선 | * |
dc.contributor.author | 최원준 | * |
dc.date.accessioned | 2016-08-28T12:08:41Z | - |
dc.date.available | 2016-08-28T12:08:41Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-6895 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221041 | - |
dc.description.abstract | We synthesized homologated truncated 4′-thioadenosine analogues 3 in which a methylene (CH2) group was inserted in place of the glycosidic bond of a potent and selective A3 adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of the A3 adenosine receptor. However, all homologated nucleosides were devoid of binding affinity at all subtypes of adenosine receptors, indicating that free rotation through the single bond allowed the compound to adopt an indefinite number of conformations, disrupting the favorable binding interaction essential for receptor recognition. © 2010 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Design, synthesis, and binding of homologated truncated 4′-thioadenosine derivatives at the human A3 adenosine receptors | * |
dc.type | Article | * |
dc.relation.issue | 19 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7015 | * |
dc.relation.lastpage | 7021 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2010.08.018 | * |
dc.identifier.wosid | WOS:000281964300008 | * |
dc.identifier.scopusid | 2-s2.0-77956651324 | * |
dc.author.google | Lee H.W. | * |
dc.author.google | Kim H.O. | * |
dc.author.google | Choi W.J. | * |
dc.author.google | Choi S. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Park S.-G. | * |
dc.author.google | Yoo L. | * |
dc.author.google | Jacobson K.A. | * |
dc.author.google | Jeong L.S. | * |
dc.contributor.scopusid | 정낙신(16028528200) | * |
dc.contributor.scopusid | 최선(8659831000) | * |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | * |
dc.date.modifydate | 20240305081003 | * |