DSpace at EWHA: Transforming growth factor-β1 bioassay involving matrix metalloproteinase-2 induction

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DC Field	Value	Language
dc.contributor.author	이화정	*
dc.date.accessioned	2016-08-28T12:08:40Z	-
dc.date.available	2016-08-28T12:08:40Z	-
dc.date.issued	2010	*
dc.identifier.issn	1079-9907	*
dc.identifier.other	OAK-6885	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/221034	-
dc.description.abstract	The transforming growth factor-β1 (TGF-β1) bioassay developed in this study monitors increased luciferase activity in MCF10A cells containing the matrix metalloproteinase-2 (MMP-2) promoter with a luciferase reporter and treated with increasing TGF-β1 concentrations. The response was linear in the concentration range from 75 to 2,500pg/mL. The abilities of 3 types of TGF-β in inducing MMP-2 were different. The luciferase activity induced by TGF-β1 was about 2 times more than that by TGF-β2 and TGF-β3. The MMP-2 promoter bioassay showed greater reproducibility (coefficient of variation [CV] 10%) than the previously developed anticell proliferation assay of TF-1 cell (CV 16%) and the MMP-2 zymogram assay (CV 40%). Mary Ann Liebert, Inc.	*
dc.language	English	*
dc.title	Transforming growth factor-β1 bioassay involving matrix metalloproteinase-2 induction	*
dc.type	Article	*
dc.relation.issue	9	*
dc.relation.volume	30	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	667	*
dc.relation.lastpage	672	*
dc.relation.journaltitle	Journal of Interferon and Cytokine Research	*
dc.identifier.doi	10.1089/jir.2009.0058	*
dc.identifier.wosid	WOS:000281861800005	*
dc.identifier.scopusid	2-s2.0-77956561630	*
dc.author.google	Kim G.-H.	*
dc.author.google	Kang S.-Y.	*
dc.author.google	Kwak H.-J.	*
dc.author.google	Baek K.-M.	*
dc.author.google	Hong S.-H.	*
dc.author.google	Lee H.-J.	*
dc.author.google	Sohn Y.-W.	*
dc.contributor.scopusid	이화정(57102029300)	*
dc.date.modifydate	20240118154655	*