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Rationally designed fluorescence turn-on sensors: A new design strategy based on orbital control

Title
Rationally designed fluorescence turn-on sensors: A new design strategy based on orbital control
Authors
Jung H.S.Ko K.C.Lee J.H.Kim S.H.Bhuniya S.Lee J.Y.Kim Y.Kim S.J.Kim J.S.
Ewha Authors
김성진김영미
SCOPUS Author ID
김성진scopus; 김영미scopus
Issue Date
2010
Journal Title
Inorganic Chemistry
ISSN
0020-1669JCR Link
Citation
vol. 49, no. 18, pp. 8552 - 8557
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Herein, we explore a new strategy in the chemo-sensor field for fluorescence amplification upon binding with metal ions based on controlled participation of the nitrogen lone pair orbital. The basic architecture of the sensor entails a fluorophore, the sp2 hybridized nitrogen lone pair (-C=N-), and a chelator site referred to as the control part. Though nonplanar and nonfluorescent, compound IC1 achieved pseudo planarity from binding with Zn2+ as indicated by the increased fluorescence signal. Its other analogue (IC2) is also planar, and unlike IC1-Zn2+ was fluorescent with a lack of binding affinity to metal ions. The time-dependent density functional theory (TDDFT) calculations revealed that the fluorescence amplification was due to the blocking of the nitrogen lone pair orbital; unlikely geometrical rearrangements were insignificant. This could indicate a breakthrough concept in the future design of fluorescent turn-on sensors. © 2010 American Chemical Society.
DOI
10.1021/ic101165k
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자연과학대학 > 화학·나노과학전공 > Journal papers
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