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Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase

Title
Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase
Authors
Kim A.D.Kang K.A.Zhang R.Lim C.M.Kim H.S.Kim D.H.Jeon Y.J.Lee C.H.Park J.Chang W.Y.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2010
Journal Title
Environmental Toxicology and Pharmacology
ISSN
1382-6689JCR Link
Citation
vol. 30, no. 2, pp. 134 - 140
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Previous studies have shown that the ginseng saponin metabolite, Compound K (20-O-d-glucopyranosyl-20(S)-protopanaxadiol, IH901), suppresses proliferation of various cancers and induces apoptosis. AMP-activated protein kinase (AMPK) is a sensor of cellular energy states and is involved in apoptosis of cancer cells. We hypothesized that Compound K may exert cytotoxicity in MCF-7 human breast cancer cells through modulation of AMPK, followed by a decrease in cyclooxygenase-2 (COX-2) expression. Compound K inhibited cell growth, induced apoptosis via generation of reactive oxygen species (ROS), as well as decreasing COX-2 expression and prostaglandin E2 (PGE2) levels. These effects of Compound K were induced via an AMPK-dependent pathway and were abrogated by a specific AMPK inhibitor. These results suggest that Compound K induced apoptosis by modulating AMPK-COX-2 signaling in MCF-7 human breast cancer cells. © 2010 Elsevier B.V.
DOI
10.1016/j.etap.2010.04.008
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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