Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T12:08:37Z | - |
dc.date.available | 2016-08-28T12:08:37Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1382-6689 | * |
dc.identifier.other | OAK-6834 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221002 | - |
dc.description.abstract | Previous studies have shown that the ginseng saponin metabolite, Compound K (20-O-d-glucopyranosyl-20(S)-protopanaxadiol, IH901), suppresses proliferation of various cancers and induces apoptosis. AMP-activated protein kinase (AMPK) is a sensor of cellular energy states and is involved in apoptosis of cancer cells. We hypothesized that Compound K may exert cytotoxicity in MCF-7 human breast cancer cells through modulation of AMPK, followed by a decrease in cyclooxygenase-2 (COX-2) expression. Compound K inhibited cell growth, induced apoptosis via generation of reactive oxygen species (ROS), as well as decreasing COX-2 expression and prostaglandin E2 (PGE2) levels. These effects of Compound K were induced via an AMPK-dependent pathway and were abrogated by a specific AMPK inhibitor. These results suggest that Compound K induced apoptosis by modulating AMPK-COX-2 signaling in MCF-7 human breast cancer cells. © 2010 Elsevier B.V. | * |
dc.language | English | * |
dc.title | Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 134 | * |
dc.relation.lastpage | 140 | * |
dc.relation.journaltitle | Environmental Toxicology and Pharmacology | * |
dc.identifier.doi | 10.1016/j.etap.2010.04.008 | * |
dc.identifier.wosid | WOS:000281339500007 | * |
dc.identifier.scopusid | 2-s2.0-77955423206 | * |
dc.author.google | Kim A.D. | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Zhang R. | * |
dc.author.google | Lim C.M. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Jeon Y.J. | * |
dc.author.google | Lee C.H. | * |
dc.author.google | Park J. | * |
dc.author.google | Chang W.Y. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |