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dc.contributor.author김희선*
dc.date.accessioned2016-08-28T12:08:37Z-
dc.date.available2016-08-28T12:08:37Z-
dc.date.issued2010*
dc.identifier.issn1382-6689*
dc.identifier.otherOAK-6834*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221002-
dc.description.abstractPrevious studies have shown that the ginseng saponin metabolite, Compound K (20-O-d-glucopyranosyl-20(S)-protopanaxadiol, IH901), suppresses proliferation of various cancers and induces apoptosis. AMP-activated protein kinase (AMPK) is a sensor of cellular energy states and is involved in apoptosis of cancer cells. We hypothesized that Compound K may exert cytotoxicity in MCF-7 human breast cancer cells through modulation of AMPK, followed by a decrease in cyclooxygenase-2 (COX-2) expression. Compound K inhibited cell growth, induced apoptosis via generation of reactive oxygen species (ROS), as well as decreasing COX-2 expression and prostaglandin E2 (PGE2) levels. These effects of Compound K were induced via an AMPK-dependent pathway and were abrogated by a specific AMPK inhibitor. These results suggest that Compound K induced apoptosis by modulating AMPK-COX-2 signaling in MCF-7 human breast cancer cells. © 2010 Elsevier B.V.*
dc.languageEnglish*
dc.titleGinseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase*
dc.typeArticle*
dc.relation.issue2*
dc.relation.volume30*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage134*
dc.relation.lastpage140*
dc.relation.journaltitleEnvironmental Toxicology and Pharmacology*
dc.identifier.doi10.1016/j.etap.2010.04.008*
dc.identifier.wosidWOS:000281339500007*
dc.identifier.scopusid2-s2.0-77955423206*
dc.author.googleKim A.D.*
dc.author.googleKang K.A.*
dc.author.googleZhang R.*
dc.author.googleLim C.M.*
dc.author.googleKim H.S.*
dc.author.googleKim D.H.*
dc.author.googleJeon Y.J.*
dc.author.googleLee C.H.*
dc.author.googlePark J.*
dc.author.googleChang W.Y.*
dc.author.googleHyun J.W.*
dc.contributor.scopusid김희선(57191372551)*
dc.date.modifydate20240118140922*
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의과대학 > 의학과 > Journal papers
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